Alcoholic liver steatosis in mice is aggravated by low-protein diet and reversed by FXR agonist
نویسندگان
چکیده
Background Hepatic steatosis refers to the accumulation of triglycerides in hepatocytes, and it can be attributed to excessive ethanol consumption. The liver is the main organ of ethanol biotransformation and therefore, it can suffer with oxidative stress generated by ethanol. Since the FXR agonist 6ECDCA regulates adipose cell function, the aim of this work is to evaluate the participation of oxidative stress in ethanol-induced liver lesions and test the effects of FXR agonist against alcoholic liver steatosis development. For thus, diets with different amount of protein were used.
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2012